1020 Comprehensive search for therapeutic targets and understanding of fibrosis in hidradenitis suppurativa
نویسندگان
چکیده
Hidradenitis suppurativa is a neutrophilic skin dermatosis characterized by painful chronic inflammation and fistula formation in terminal hair follicles, resulting tissue-destructive fibrotic scar formation. considered to be an autoinflammatory disease like pustular psoriasis pyoderma gangrenosum. Anti-TNFα anti-IL-17 preparations are known partly effective, however there some cases which these drugs not effective. There no particularly effective against fibrosis scarring, since the pathology of exclusively understood hidradenitis suppurativa. Our purpose identify cytokines or factor(s) involved suppurativa, their producing cells elucidate mechanism from long-term fibrosis. We extracted RNA FFPE tissues gangrenosum, psoriasis, performed transcriptome analysis. Genes including CTGF, COL1A1, COL3A1, COL14A1, ELN were highly expressed than other dermatoses. These collagens elastin also confirmed for accumulation lesion immunohistochemical Furthermore, dense infiltration MZB1-positive B was found at dermal CD79+, CD38+, CD138+, but CD20- cells, CTGF. In presence primary cultured fibroblasts induced gene expression COL3A1 depending on concentration. observations imply that MZB1+ infiltrating sclerotic can main source persistent
منابع مشابه
Hidradenitis suppurativa.
BACKGROUND Hidradenitis suppurativa is a chronic, recurrent, suppurative cutaneous disease. Despite its incidence, optimal medical or surgical treatment remains unclear. This review describes the disease, ranging from pathogenesis to treatment and prognosis. METHODS Articles were sourced from PubMed and Medline, using the MeSH terms 'hidradenitis suppurativa' and 'acne inversa'. Selection of ...
متن کاملHidradenitis suppurativa.
Hidradenitis suppurativa is a chronic, relapsing, inflammatory disease process that primarily involves the axilla and/or inguinal region and does not manifest itself until after puberty. Typically, the process begins as a local occlusive disease of a sweat gland; secondary bacterial infection then occurs. The early stages of hidradenitis suppurativa are usually managed by the dermatologist. Onc...
متن کاملHidradenitis suppurativa
Hidradenitis suppurativa is a chronic disease characterized by recurrent, painful, deep-seated, rounded nodules and abscesses of apocrine gland-bearing skin. Subsequent suppuration, sinus tracts and hypertrophic scarring are its main features. Onset is usually after puberty, although it is most common during the third decade and may persist in old age. The disease tends to be chronic and may de...
متن کاملHidradenitis suppurativa
Key-words Disease name Definition Diagnostic criteria Clinical description Complications Associated diseases Differential diagnostic Etiology Epidemiology Treatment Unresolved questions References
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.1031